Clinic for Obstetrics, Gynecology and Andrology, University for Veterinary Sciences, Vienna, Austria.
Theriogenology. 2010 Jul 15;74(2):229-35. doi: 10.1016/j.theriogenology.2010.02.006. Epub 2010 May 10.
Treatment with the progestin altrenogest is widely used in pregnant mares. The fact that foals born from healthy mares treated with altrenogest until term suffered from neonatal problems raises the question of direct effects of altrenogest on vital functions in the neonate. We have therefore investigated altrenogest concentrations in maternal and neonatal blood plasma and in fetal fluids. Pregnant mares were treated with altrenogest orally once daily (0,088 mg/kg bodyweight, n = 7) or left untreated (n = 8) from 280 d of gestation until foaling. Altrenogest concentration was determined in plasma of the mares, their foals and in amniotic and allantoic fluid. The concentration of altrenogest in plasma from treated mares (2.6 +/- 1.0 ng/mL) was significantly lower than in plasma from their foals immediately after birth (5.6 +/- 1.9 ng/mL; p < 0.05), but was significantly higher than in their fetal fluids (amniotic fluid: 0.4 +/- 0.1 ng/mL; p < 0.05; allantoic fluid: 3.0 +/- 1.5 ng/mL). Altrenogest was undetectable in maternal and fetal plasma and fetal fluids of control pregnancies at all times. Altrenogest concentration in plasma of foals from treated mares was strongly correlated to the altrenogest concentration in plasma of their dams (r = 0.938, p < 0.001) and in amniotic (r = 0.886, p < 0.001) and allantoic fluid (r = 0.562, p < 0.05). A significant decrease in altrenogest concentration between the time periods 0-15 min, 30-120 min, and 180-360 min after parturition was seen in the plasma from foals born to altrenogest-treated mares. In conclusion, our data demonstrate that altrenogest reaches the equine fetus at high concentrations.
孕激素烯丙孕素在妊娠母马中的治疗应用广泛。然而，来自健康母马的驹在使用烯丙孕素治疗至足月后，出现了新生儿问题，这引发了烯丙孕素是否会直接影响新生儿生命功能的问题。因此，我们研究了母马和新生儿血浆以及胎儿液中的烯丙孕素浓度。从妊娠 280 天开始，将妊娠母马（n = 7）或未治疗的母马（n = 8）每天口服 0.088mg/kg 体重的烯丙孕素直至分娩。检测母马、驹及其胎牛羊水和尿囊液中的烯丙孕素浓度。治疗母马的血浆中烯丙孕素浓度（2.6 ± 1.0ng/mL）明显低于驹出生后即刻的血浆浓度（5.6 ± 1.9ng/mL；p < 0.05），但明显高于其胎儿液中的浓度（羊水：0.4 ± 0.1ng/mL；p < 0.05；尿囊液：3.0 ± 1.5ng/mL）。在所有时间点，对照组母马和胎儿的血浆及胎儿液中均未检测到烯丙孕素。来自烯丙孕素治疗母马的驹的血浆中烯丙孕素浓度与母马的烯丙孕素浓度（r = 0.938，p < 0.001）以及羊水（r = 0.886，p < 0.001）和尿囊液（r = 0.562，p < 0.05）呈强相关。来自烯丙孕素治疗母马的驹的血浆中，在分娩后 0-15 分钟、30-120 分钟和 180-360 分钟三个时间段内，烯丙孕素浓度呈显著下降趋势。总之，我们的数据表明，烯丙孕素可在母马胎儿中达到高浓度。
