1 型肌强直性营养不良患者瘦素与代谢综合征。

Leptin and the metabolic syndrome in patients with myotonic dystrophy type 1.

机构信息

Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia.

出版信息

Acta Neurol Scand. 2010 Feb;121(2):94-8. doi: 10.1111/j.1600-0404.2009.01237.x. Epub 2009 Oct 25.

DOI:10.1111/j.1600-0404.2009.01237.x

PMID:19804472

Abstract

OBJECTIVES

To evaluate serum leptin concentration and its relation to metabolic syndrome (MSy) in non-diabetic patients with myotonic dystrophy type 1 (DM1).

MATERIALS AND METHODS

This study included 34 DM1 patients, and the same number of healthy subjects matched for age, sex and body mass index (BMI).

RESULTS

DM1 patients had increased BMI and insulin resistance, and increased leptin and insulin concentrations, but the other features of MSy such as diabetes, glucose intolerance and hypertension were not detected in DM1 patients. Serum leptin levels were higher in patients with DM1 than in healthy controls (8.5 +/- 6.6 ng/ml vs 3.6 +/- 2.9 ng/ml in men, and 13.9 +/- 10.0 ng/ml vs 10.9 +/- 6.9 ng/ml in women, respectively). In DM1 patients, leptin levels correlated with BMI, fasting insulin and insulin resistance (HOMA) (P < 0.01).

CONCLUSIONS

The leptin overproduction correlated with insulin resistance in DM1 patients but the significance of this finding remains unclear.

摘要

目的

评估非糖尿病 1 型肌强直性营养不良（DM1）患者的血清瘦素浓度及其与代谢综合征（MSy）的关系。

材料和方法

本研究纳入了 34 例 DM1 患者，并纳入了年龄、性别和体重指数（BMI）相匹配的相同数量的健康对照者。

结果

DM1 患者 BMI 和胰岛素抵抗增加，瘦素和胰岛素浓度增加，但 DM1 患者未检测到 MSy 的其他特征，如糖尿病、葡萄糖耐量异常和高血压。DM1 患者的血清瘦素水平高于健康对照组（男性分别为 8.5 +/- 6.6 ng/ml 和 3.6 +/- 2.9 ng/ml，女性分别为 13.9 +/- 10.0 ng/ml 和 10.9 +/- 6.9 ng/ml）。在 DM1 患者中，瘦素水平与 BMI、空腹胰岛素和胰岛素抵抗（HOMA）相关（P < 0.01）。