凝聚素（g）将交叉控制在少数几个断裂处。

Condensin(g) crossover control to a few breaks.

作者信息

Boulton Simon J

机构信息

DNA Damage Response laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, UK.

出版信息

Cell. 2009 Oct 2;139(1):21-3. doi: 10.1016/j.cell.2009.09.016.

DOI:10.1016/j.cell.2009.09.016

PMID:19804748

Abstract

Meiotic chromosome pairs must receive at least one crossover to ensure proper segregation at the first meiotic division. Mets and Meyer (2009) now present compelling evidence that the establishment of higher-order chromosome structure by a condensin complex regulates crossover recombination by controlling the distribution and frequency of meiotic double-strand breaks.

摘要

减数分裂染色体对必须至少发生一次交叉，以确保在第一次减数分裂时正确分离。梅茨和迈耶（2009年）现在提供了令人信服的证据，即凝聚素复合物建立的高阶染色体结构通过控制减数分裂双链断裂的分布和频率来调节交叉重组。