恰加斯病的触珠蛋白基因型。
Haptoglobin genotypes in Chagas' disease.
机构信息
Department of Clinical Pathology, School of Medical Sciences, State University of Campinas-UNICAMP, São Paulo, Brazil.
出版信息
Clin Biochem. 2010 Feb;43(3):314-6. doi: 10.1016/j.clinbiochem.2009.09.020. Epub 2009 Oct 3.
OBJECTIVES
To investigate the existence of an association between haptoglobin (Hp) genotypes and the severity of heart complications in Chagas' disease.
DESIGN AND METHODS
Hp genotyping was performed by PCR in 107 Brazilian patients sub-classified in asymptomatic, with mild heart disease and with severe heart disease.
RESULTS
Multiple logistic regression (R(2)=24%) indicated that patients with the Hp1-1 genotype have lower probability of developing the severe heart complications.
CONCLUSION
The Hp polymorphism may influence the clinical evolution of Chagas' disease.
目的
研究血红蛋白（Hp）基因型与恰加斯病心脏并发症严重程度之间的关联。
设计与方法
对 107 名巴西患者进行 PCR 法 Hp 基因分型，这些患者分为无症状、轻度心脏病和重度心脏病。
结果
多元逻辑回归（R²=24%）表明，Hp1-1 基因型患者发生严重心脏并发症的概率较低。
结论
Hp 多态性可能影响恰加斯病的临床演变。
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