在一组独立的家系中，躁郁症与凝血因子IX区域无关。

Manic depressive illness not linked to factor IX region in an independent series of pedigrees.

作者信息

Gejman P V, Detera-Wadleigh S, Martinez M M, Berrettini W H, Goldin L R, Gelernter J, Hsieh W T, Gershon E S

机构信息

Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892.

出版信息

Genomics. 1990 Dec;8(4):648-55. doi: 10.1016/0888-7543(90)90251-o.

DOI:10.1016/0888-7543(90)90251-o

PMID:1980485

Abstract

We studied seven informative kindreds segregating for manic depressive illness (MDI), consistent with X-chromosome transmission of the trait (families do not show affective disease in both a father and a son), using markers mapped to the region of Xq27-Xq28. The lod scores were consistently below -2 in the region extending from about 10 cM centromeric from the Factor IX locus (F9) to the colorblindness region. This study does not replicate previous reports of linkage of MDI to Factor IX (Xq27) and colorblindness region (Xq28) chromosomal markers in other kindreds.

摘要

我们研究了7个与躁郁症（MDI）相关的信息家族，该病症与性状的X染色体传递一致（家族中父亲和儿子不会同时患情感性疾病），使用定位到Xq27 - Xq28区域的标记。从因子IX基因座（F9）着丝粒约10厘摩处到色盲区域的延伸区域，连锁值一直低于-2。本研究未能重复先前关于其他家族中MDI与因子IX（Xq27）和色盲区域（Xq28）染色体标记连锁的报道。