X染色体上的多态性DNA标记与躁狂抑郁症

Polymorphic DNA marker on X chromosome and manic depression.

作者信息

Mendlewicz J, Simon P, Sevy S, Charon F, Brocas H, Legros S, Vassart G

出版信息

Lancet. 1987 May 30;1(8544):1230-2. doi: 10.1016/s0140-6736(87)92685-7.

Abstract

Heredity is an important factor in vulnerability to manic depression. A genetic linkage has been demonstrated between manic depression and coagulation factor IX at Xq27 with a TaqI polymorphism at the F9 locus in DNA samples from peripheral leucocytes of manic depressive probands and relatives in 10 informative families. Statistical analysis of the pedigrees gave a maximum lod score of 3.10 at a recombination fraction of 0.11, demonstrating a linkage between a manic depressive locus and the F9 locus in the Xq27 region.

摘要

遗传是导致躁郁症易感性的一个重要因素。在10个信息充分的家庭中，对躁郁症先证者及其亲属外周血白细胞DNA样本进行研究，结果显示，躁郁症与位于Xq27的凝血因子IX之间存在基因连锁，F9基因座存在TaqI多态性。对这些家系进行统计分析，在重组率为0.11时，最大对数优势得分为3.10，表明在Xq27区域的一个躁郁症基因座与F9基因座之间存在连锁关系。