McClelland Sarah E, Burrell Rebecca A, Swanton Charles
Translational Cancer Therapeutics Laboratory, Cancer Research UK, London Research Institute, London, UK.
Cell Cycle. 2009 Oct 15;8(20):3262-6. doi: 10.4161/cc.8.20.9690. Epub 2009 Oct 31.
Chromosomal instability (CIN) is defined as continual gain or loss of whole chromosomes or fractions of chromosomes and is a major cause of the genomic instability that characterizes most solid tumors. CIN is associated with intrinsic resistance to taxanes, acquired multidrug resistance and poor prognosis in many solid tumors, although recent evidence has shown that platinum agents, such as carboplatin, may specifically target CIN cancers.
染色体不稳定性（CIN）被定义为整条染色体或染色体片段的持续获得或丢失，是大多数实体瘤所具有的基因组不稳定的主要原因。CIN与对紫杉烷类药物的内在抗性、获得性多药耐药以及许多实体瘤的不良预后相关，尽管最近的证据表明，铂类药物，如卡铂，可能特异性地靶向CIN癌症。
