Laboratory of Environmental Chemodynamics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan.
Food Chem Toxicol. 2010 Feb;48(2):465-9. doi: 10.1016/j.fct.2009.09.037. Epub 2009 Oct 4.
The element arsenic is a carcinogen and toxic for humans and other living organisms. Some seaweeds contain high amounts of inorganic arsenic (iAs). In particular, Hijikia fusiforme has a high iAs content of approximately 50%. In this study, we examined the absorption, metabolism, excretion, and accumulation of arsenic compounds in mice after the administration of Hijiki. The single-dose experiment, wherein a single dose of cooked Hijiki was administered to the mice, revealed that the urinary and fecal excretion of arsenic compounds was the highest on the first day of dosing, and it became clear that 66-92% of arsenic was excreted within 3 days after administration of the first dose. The repeated-dose experiment, wherein repeated doses of cooked or dried Hijiki were administered to the mice, arsenic was detected in all the tissues, but only approximately 5% of the administered dose of arsenic was detected as residual arsenic. These results suggest that the arsenic present in cooked Hijiki is accumulated in very small amounts in mice.
砷元素是一种致癌物质，对人类和其他生物都具有毒性。一些海藻含有大量无机砷（iAs）。特别是，羊栖菜的无机砷含量很高，约为 50%。在这项研究中，我们研究了小鼠在食用羊栖菜后砷化合物的吸收、代谢、排泄和积累。单次剂量实验中，给小鼠喂食了一顿煮熟的羊栖菜，结果表明，砷化合物在第一天的排泄量最高，并且在第一次给药后 3 天内，有 66-92%的砷被排泄。重复剂量实验中，给小鼠喂食了重复剂量的煮熟或干燥的羊栖菜，结果表明，砷在所有组织中都有检测到，但只有约 5%的给予剂量的砷被检测为残留砷。这些结果表明，煮熟的羊栖菜中的砷在小鼠体内积累的量非常少。
