Mardis Elaine R, Wilson Richard K
The Genome Center, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Hum Mol Genet. 2009 Oct 15;18(R2):R163-8. doi: 10.1093/hmg/ddp396.
A genomic era of cancer studies is developing rapidly, fueled by the emergence of next-generation sequencing technologies that provide exquisite sensitivity and resolution. This article discusses several areas within cancer genomics that are being transformed by the application of new technology, and in the process are dramatically expanding our understanding of this disease. Although, we anticipate that there will be many exciting discoveries in the near future, the ultimate success of these endeavors rests on our ability to translate what is learned into better diagnosis, treatment and prevention of cancer.
随着提供超高灵敏度和分辨率的新一代测序技术的出现，癌症研究的基因组时代正在迅速发展。本文讨论了癌症基因组学中正在因新技术应用而发生变革的几个领域，在此过程中极大地扩展了我们对这种疾病的理解。尽管我们预计在不久的将来会有许多令人兴奋的发现，但这些努力的最终成功取决于我们将所学知识转化为更好地诊断、治疗和预防癌症的能力。
