肌醇-1,4,5-三磷酸和不可水解的鸟苷三磷酸类似物诱导了苹果螺神经元细胞内储存库的钙释放。
Inositol-1,4,5-trisphosphate and non-hydrolysable GTP analogue induced calcium release from intracellular stores of the Helix pomatia neurons.
作者信息
Belan P V, Osipenko O N, Tepikin A V
机构信息
A. A. Bogomoletz Institute of Physiology, Academy of Science of Ukranian S.S.R., Kiev.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;96(1):45-7. doi: 10.1016/0742-8413(90)90042-8.
PMID:1980882
Abstract
- Cytoplasmic Ca2+ concentration ICaIin and membrane potential of single Helix pomatia neurons was studied by Fura-2 fluorescence measurement and conventional current clamp methods. 2. Intracellular injection of inositol-1,4,5-trisphosphate (IP3) and nonhydrolysable GTP analogue (Gpp/NH/p) led to a rise of ICaIin; in contrast, GTP injection did not cause significant ICaIin changes. 3. We suggest that both IP3 and Gpp/NH/p directly activated Ca release from intracellular stores.
摘要
- 通过Fura-2荧光测量法和传统电流钳法研究了单枚苹果蜗牛神经元的细胞质Ca2+浓度（[Ca2+]i）和膜电位。2. 向细胞内注射肌醇-1,4,5-三磷酸（IP3）和不可水解的GTP类似物（Gpp/NH/p）会导致[Ca2+]i升高；相反，注射GTP不会引起[Ca2+]i的显著变化。3. 我们认为IP3和Gpp/NH/p均可直接激活细胞内钙库的钙释放。
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