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本文引用的文献

1
Decreased saliva secretion and down-regulation of AQP5 in submandibular gland in irradiated rats.照射大鼠下颌下腺唾液分泌减少及水通道蛋白5下调。
Radiat Res. 2006 Jun;165(6):678-87. doi: 10.1667/RR3569.1.
2
Post-treatment plasma transforming growth factor beta 1 (TGF-beta1) level predicts for late morbidity in patients with advanced head and neck cancer.
Neoplasma. 2005;52(5):393-7.
3
On the mechanism of salivary gland radiosensitivity.关于唾液腺放射敏感性的机制。
Int J Radiat Oncol Biol Phys. 2005 Jul 15;62(4):1187-94. doi: 10.1016/j.ijrobp.2004.12.051.
4
Medical applications of transforming growth factor-beta.转化生长因子-β的医学应用
Clin Med Res. 2003 Jan;1(1):13-20. doi: 10.3121/cmr.1.1.13.
5
Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse.细胞凋亡与增殖之间的失衡导致小鼠唾液腺的晚期放射性损伤。
Physiol Res. 2006;55(1):89-95. doi: 10.33549/physiolres.930739. Epub 2005 Apr 26.
6
Disability in patients with head and neck cancer.头颈癌患者的残疾情况。
Arch Otolaryngol Head Neck Surg. 2004 Jun;130(6):764-9. doi: 10.1001/archotol.130.6.764.
7
The enigmatic mechanism of irradiation-induced damage to the major salivary glands.辐射诱导大唾液腺损伤的神秘机制。
Oral Dis. 2002 May;8(3):141-6. doi: 10.1034/j.1601-0825.2002.02838.x.
8
Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation.通过Smad途径的转化生长因子-β信号传导：在细胞外基质基因表达和调控中的作用。
J Invest Dermatol. 2002 Feb;118(2):211-5. doi: 10.1046/j.1523-1747.2002.01641.x.
9
Consequential late effects in normal tissues.
Radiother Oncol. 2001 Dec;61(3):223-31. doi: 10.1016/s0167-8140(01)00429-7.
10
Early to late sparing of radiation damage to the parotid gland by adrenergic and muscarinic receptor agonists.肾上腺素能和毒蕈碱受体激动剂对腮腺辐射损伤的早期至晚期保护作用。
Br J Cancer. 2001 Sep 28;85(7):1055-63. doi: 10.1054/bjoc.2001.2038.

辐射致大鼠颌下腺细胞凋亡及水通道蛋白 5 和转化生长因子-β表达的变化

Apoptosis and expression of AQP5 and TGF-beta in the irradiated rat submandibular gland.

机构信息

Department of Radiation Oncology, Chung-Ang University Hospital, Seoul, Korea.

出版信息

Cancer Res Treat. 2009 Sep;41(3):145-54. doi: 10.4143/crt.2009.41.3.145. Epub 2009 Sep 28.

DOI:10.4143/crt.2009.41.3.145
PMID:19809564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2757666/
Abstract

PURPOSE

To evaluate the effect of X-ray irradiation on apoptosis and change of expression of aquaporin 5 (AQP5) and transforming growth factor-β(TGF-β) in the rat submandibular gland (SMG).

MATERIALS AND METHODS

SMGs of 120 male Sprague-Dawley rats were irradiated with a single X-ray dose (3, 10, 20, or 30 Gy). At the early and late post-irradiation phase, apoptosis was measured by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) method, and expression of AQP5 and TGF-β was determined by immunohistochemical staining.

RESULTS

At the late post-irradiation phase, increased apoptosis was evident and marked decreases of expression of AQP5 expression by acinar cells and TGF-β expression by ductal cells were evident.

CONCLUSION

Apoptosis after X-ray irradiation develops relatively late in rat SMG. Irradiation reduces AQP5 and TGF-β expression in different SMG cell types.

摘要

目的

评估 X 射线照射对大鼠下颌下腺 (SMG) 细胞凋亡及水通道蛋白 5 (AQP5) 和转化生长因子-β (TGF-β) 表达变化的影响。

材料与方法

120 只雄性 Sprague-Dawley 大鼠的 SMG 接受单次 X 射线照射（3、10、20 或 30 Gy）。在照射后的早期和晚期，通过末端脱氧核苷酸转移酶生物素-dUTP 缺口末端标记法 (TUNEL) 测量细胞凋亡，通过免疫组织化学染色测定 AQP5 和 TGF-β 的表达。

结果

在照射后的晚期，可见明显的细胞凋亡，且腺泡细胞 AQP5 表达和导管细胞 TGF-β 表达明显减少。

结论

X 射线照射后大鼠 SMG 中的细胞凋亡发生较晚。照射会降低不同 SMG 细胞类型中 AQP5 和 TGF-β 的表达。