Arda Hatice, Oner Ayse, Gumus Koray, Karakucuk Sarper, Mirza Ertugrul
Department of Ophthalmology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey.
Doc Ophthalmol. 2009 Dec;119(3):225-8. doi: 10.1007/s10633-009-9199-0. Epub 2009 Oct 7.
The purpose of this study is to describe clinical and electrophysiological findings of three patients with unilateral extensive peripapillary myelinated nerve fibers. Three patients with unilateral extensive peripapillary myelinated nerve fibers were examined. A complete ophthalmologic examination including uncorrected and best spectacle corrected visual acuities (UCVA, BSCVA) on Snellen charts, dilated fundoscopy, fundus fluorescein angiography (FFA), optical coherence tomography (OCT), perimetry and electrophysiological tests was performed. ERG results of both eyes were normal in all cases. FFA showed hypofluorescence at the myelinated nerve fibers (MNF) area in the affected eyes. We found a visual field defect resembling arcuat scotom at perimetry of the affected eyes. In OCT, there was hyper-reflectivity in reply to MNF. In all cases, pattern ERG results of the affected eyes showed decreased amplitudes and increased latencies of P50 and N95 waves. P100 amplitudes of PVER and FVER were decreased, and latencies were increased in all affected eyes. Extensive peripapillary myelinated nerve fibers may cause changes in PERG and VER.
本研究的目的是描述三名单侧广泛视乳头周围有髓神经纤维患者的临床和电生理表现。对三名单侧广泛视乳头周围有髓神经纤维患者进行了检查。进行了全面的眼科检查，包括使用斯内伦视力表测量未矫正和最佳矫正视力（UCVA、BSCVA）、散瞳眼底检查、眼底荧光血管造影（FFA）、光学相干断层扫描（OCT）、视野检查和电生理测试。所有病例双眼的视网膜电图（ERG）结果均正常。FFA显示患眼有髓神经纤维（MNF）区域出现低荧光。在患眼的视野检查中，我们发现了类似弓形暗点的视野缺损。在OCT中，MNF区域呈现高反射性。所有病例中，患眼的图形视网膜电图结果显示P50和N95波的振幅降低、潜伏期延长。所有患眼的图形视觉诱发电位（PVER）和闪光视觉诱发电位（FVER）的P100振幅降低，潜伏期延长。广泛的视乳头周围有髓神经纤维可能导致图形视网膜电图（PERG）和视觉诱发电位（VER）的改变。
