Fellay Jacques
Center for Human Genome Variation, Institute for Genome Sciences & Policy, Duke University, Durham, NC, USA.
Antivir Ther. 2009;14(6):731-8. doi: 10.3851/IMP1253.
HIV host genetic studies seek to describe as comprehensively as possible the effect of human genetic variation on the individual response to HIV type-1 (HIV-1) infection. Many associations between specific gene variants and HIV-1 disease outcomes have been reported over the past 15 years. Although most of them have yet to be confirmed or have been proven false-positives, the identification of several definitive genotype-phenotype associations has shed new light on HIV-1 pathogenesis. This review discusses these results in the context of the new genome-wide approaches that now make it possible to globally assess the influence of the host genome on HIV-1-related outcomes.
HIV宿主基因研究旨在尽可能全面地描述人类基因变异对个体对1型HIV（HIV-1）感染反应的影响。在过去15年里，已经报道了特定基因变异与HIV-1疾病结局之间的许多关联。尽管其中大多数尚未得到证实或已被证明为假阳性，但一些明确的基因型-表型关联的确定为HIV-1发病机制带来了新的启示。本综述在新的全基因组方法的背景下讨论了这些结果，这些方法现在使全面评估宿主基因组对HIV-1相关结局的影响成为可能。
