Suzuki T, Koizumi J, Moroji T, Sakuma K, Hori M, Hori T
Department of Psychiatry, University of Tsukuba, Japan.
Acta Psychiatr Scand. 1990 Dec;82(6):454-7. doi: 10.1111/j.1600-0447.1990.tb03078.x.
The Pisa syndrome is not yet well characterized, although there have been increasing reports on its prevalence and the clinical features of drug-induced dystonia. In this report, we present 20 cases of the Pisa syndrome and discuss the clinical symptoms compared with those of classical types of drug-induced dystonia. The Pisa syndrome may occur not only as a subtype of acute dystonia but also as a subtype of tardive dystonia. Abnormal findings on brain CT were noted in both acute and tardive types of the Pisa syndrome, indicating that, like tardive dystonia, the Pisa syndrome may be associated with cerebral lesions. Young female patients were susceptible to both acute and tardive types of the Pisa syndrome, but the prevalence of both types of dystonia was inconsistent in these patients. Thus, it seems likely that very complicated pathophysiological changes in the brain are involved in the development of the Pisa syndrome.
尽管关于匹萨综合征的患病率及药物性肌张力障碍的临床特征的报道日益增多，但该综合征尚未得到充分描述。在本报告中，我们呈现了20例匹萨综合征病例，并与经典类型的药物性肌张力障碍的临床症状进行了讨论。匹萨综合征不仅可能作为急性肌张力障碍的一种亚型出现，也可能作为迟发性肌张力障碍的一种亚型出现。在急性和迟发性匹萨综合征类型中均发现脑部CT异常，这表明，与迟发性肌张力障碍一样，匹萨综合征可能与脑部病变有关。年轻女性患者易患急性和迟发性匹萨综合征类型，但这两种肌张力障碍类型在这些患者中的患病率并不一致。因此，匹萨综合征的发生似乎很可能涉及大脑中非常复杂的病理生理变化。
