Department of Obstetrics and Gynaecology, School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Ir J Med Sci. 2012 Sep;181(3):349-51. doi: 10.1007/s11845-009-0430-5. Epub 2009 Oct 8.
The timing of embryo transfer (ET) after in vitro fertilisation (IVF) remains controversial, and there are no reliable guidelines available to prospectively identify which patients would benefit from either day-3 or blastocyst transfer. While blastocyst transfer is generally favoured over day-3 transfers, very few IVF patients get both in the same treatment cycle.
We report on a 35.5-year-old female with tubal factor infertility who underwent IVF, which included transfer of a fresh day-3 embryo and a thawed blastocyst frozen at day 6. Transfer occurred on two separate days (days 3 and 6) in a two-stage/dual catheter fashion and resulted in a healthy term singleton livebirth.
While combined day-3 and day-5 ET has been available elsewhere for several years, this is the first description of its successful application in Ireland and confirms the effectiveness of coordinated two-stage transfer in a single IVF treatment cycle.
体外受精（IVF）后胚胎移植（ET）的时间仍然存在争议，目前尚无可靠的指南可以前瞻性地确定哪些患者将从第 3 天或囊胚转移中受益。虽然囊胚转移通常优于第 3 天的转移，但很少有 IVF 患者在同一个治疗周期中同时获得这两种方法。
我们报告了一名 35.5 岁的女性，因输卵管因素不孕接受了 IVF，其中包括新鲜第 3 天胚胎和第 6 天冷冻的解冻囊胚的转移。转移分两天（第 3 天和第 6 天）进行，采用两步/双导管方式，成功分娩了一个健康的足月单胎活产儿。
虽然联合第 3 天和第 5 天 ET 在其他地方已经使用了几年，但这是爱尔兰首次成功应用的描述，并证实了在单个 IVF 治疗周期中协调两步转移的有效性。
