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连续移植第3天胚胎和第5 - 6天囊胚可提高与囊胚培养相关的总体妊娠率。

Consecutive transfer of day 3 embryos and of day 5-6 blastocysts increases overall pregnancy rates associated with blastocyst culture.

作者信息

Phillips Simon J, Dean Nicola L, Buckett William M, Tan Seang Lin

机构信息

McGill Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.

出版信息

J Assist Reprod Genet. 2003 Nov;20(11):461-4. doi: 10.1023/b:jarg.0000006708.26464.23.

DOI:10.1023/b:jarg.0000006708.26464.23
PMID:14714825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455643/
Abstract

PURPOSE

To investigate whether the consecutive embryo transfer of day 3 embryos and of blastocyst protects against failure to reach embryo transfer and provides additional pregnancies.

METHODS

An embryo transfer was performed on day 3 following which all remaining embryos were cultured to the blastocyst stage for a possible second transfer.

RESULTS

One hundred and forty-two patients were selected for extended culture. Thirty-two of these patients did not develop blastocysts in culture, however, there were 12 pregnancies achieved in this group.

CONCLUSIONS

The consecutive transfer of day 3 embryos and blastocysts can prevent the total loss of a cycle when embryos fail to develop to the blastocyst stage in culture and thereby provide additional pregnancies.

摘要

目的

探讨连续移植第3天胚胎和囊胚是否能防止胚胎移植失败并增加妊娠率。

方法

在第3天进行胚胎移植,之后将所有剩余胚胎培养至囊胚阶段以便可能进行第二次移植。

结果

选择142例患者进行延长培养。其中32例患者在培养中未发育出囊胚,然而,该组有12例妊娠成功。

结论

连续移植第3天胚胎和囊胚可在胚胎培养过程中未能发育至囊胚阶段时防止周期完全失败,从而增加妊娠率。

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J Assist Reprod Genet. 2003 Nov;20(11):461-4. doi: 10.1023/b:jarg.0000006708.26464.23.
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本文引用的文献

1
Noninvasive assessment of human embryo nutrient consumption as a measure of developmental potential.
Fertil Steril. 2001 Dec;76(6):1175-80. doi: 10.1016/s0015-0282(01)02888-6.
2
To blastocyst or not to blastocyst? That is the question.
Hum Reprod. 2001 Apr;16(4):617-9. doi: 10.1093/humrep/16.4.617.
3
Double (consecutive) transfer of early embryos and blastocysts: aims and results.早期胚胎和囊胚的双重(连续)移植:目的与结果
Fertil Steril. 2000 Nov;74(5):936-40. doi: 10.1016/s0015-0282(00)01549-1.
4
The morphology of human pronuclear embryos is positively related to blastocyst development and implantation.人类原核胚胎的形态与囊胚发育及着床呈正相关。
Hum Reprod. 2000 Nov;15(11):2394-403. doi: 10.1093/humrep/15.11.2394.
5
Impact of reducing the number of embryos transferred from three to two in women under the age of 35 who produced three or more high-quality embryos.对35岁以下产生三个或更多高质量胚胎的女性将移植胚胎数量从三个减少到两个的影响。
Fertil Steril. 2000 Oct;74(4):820-3. doi: 10.1016/s0015-0282(00)01518-1.
6
Day 5 versus day 3 embryo transfer: a controlled randomized trial.第5天与第3天胚胎移植:一项对照随机试验。
Hum Reprod. 2000 Sep;15(9):1947-52. doi: 10.1093/humrep/15.9.1947.
7
Implantation rates after in vitro fertilization and transfer of a maximum of two embryos that have undergone three to five days of culture.体外受精并移植最多两个经过三至五天培养的胚胎后的着床率。
Fertil Steril. 2000 Jan;73(1):117-22. doi: 10.1016/s0015-0282(99)00458-6.
8
Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers.人类囊胚的培养与移植可提高着床率并减少多胚胎移植的需求。
Fertil Steril. 1998 Jan;69(1):84-8. doi: 10.1016/s0015-0282(97)00438-x.
9
Blastocyst transfer in day-5 embryo transfer depends primarily on the number of oocytes retrieved and not on age.
Fertil Steril. 1998 Jan;69(1):78-83. doi: 10.1016/s0015-0282(97)00450-0.
10
Prospective randomized trial of the effect of two flushing media on oocyte collection and fertilization rates after in vitro fertilization.两种冲洗液对体外受精后卵母细胞采集及受精率影响的前瞻性随机试验
Fertil Steril. 1997 Dec;68(6):1132-4. doi: 10.1016/s0015-0282(97)00391-9.