Department of Obstetrics and Gynecology, Faculty of Medicine, October 6th University & Air-Force Specialized Hospital- Cairo, Egypt.
Obstetrics & Gynecology Department, Al-Galaa Teaching Hospital & Air-Force Specialized Hospital, Cairo, Egypt.
JBRA Assist Reprod. 2021 Apr 27;25(2):185-192. doi: 10.5935/1518-0557.20200083.
The recent improvement in sequential media has refocused its attention on the role of human blastocysts in ART, not only because of its advantages but also because of the possible cancellation of embryo transfer when relying on blastocyst transfer only. Hence, the idea of sequential transfer on day 3 and day 5 was proposed. Objective: To compare the pregnancy outcomes of sequential embryo transfer on day 3 and day 5, versus cleavage transfer on day 3 and blastocyst transfer on day 5 in cases of recurrent implantation failure.
This was a prospective and randomized trial, in which 210 qualified patients with recurrent implantation failures undergoing IVF/ICSI were randomized into three groups, each group included 70 patients. Embryo transfer was performed in day 3 in the first group, day 5 (blastocyst transfer) in the second group and sequential embryo transfer in days 3 and 5 in the third group. We assessed pregnancy outcomes from all the three groups. Results: Clinical pregnancy and live birth rates were significantly higher in the sequential group than either group day-3 or day-5 of embryo transfer in cases with recurrent implantation failures.
Sequential embryo transfer in cases with recurrent implantation failures and adequate number of retrieved oocytes is associated with higher implantation and clinical pregnancy rates, and it is advocated for patients having an adequate number of good quality embryos.
最近连续媒体的改进重新引起了人们对人类囊胚在 ART 中的作用的关注，这不仅是因为其优势，还因为仅依靠囊胚转移可能会取消胚胎转移。因此，提出了第 3 天和第 5 天连续转移的想法。目的：比较反复着床失败患者第 3 天和第 5 天的连续胚胎转移与第 3 天的卵裂期胚胎转移和第 5 天的囊胚转移的妊娠结局。
这是一项前瞻性随机试验，其中 210 名符合条件的反复着床失败的 IVF/ICSI 患者被随机分为三组，每组 70 例。第 1 组在第 3 天进行胚胎移植，第 2 组在第 5 天（囊胚移植）进行胚胎移植，第 3 组在第 3 天和第 5 天进行连续胚胎移植。我们评估了所有三组的妊娠结局。结果：反复着床失败患者中，连续胚胎移植组的临床妊娠率和活产率明显高于第 3 天或第 5 天胚胎移植组。
对于有足够数量优质胚胎的反复着床失败患者，连续胚胎移植与更高的着床率和临床妊娠率相关，因此建议此类患者采用该方法。
