Department of Plant Sciences, University of California, Davis, CA 95616, USA.
Curr Microbiol. 2010 Jan;60(1):53-8. doi: 10.1007/s00284-009-9501-0. Epub 2009 Oct 8.
Xylella fastidiosa is a pathogenic bacterium that causes diseases in many crop species, which leads to considerable economic loss. Phenolic compounds (a group of secondary metabolites) are widely distributed in plants and have shown to possess antimicrobial properties. The anti-Xylella activity of 12 phenolic compounds, representing phenolic acid, coumarin, stilbene and flavonoid, was evaluated using an in vitro agar dilution assay. Overall, these phenolic compounds were effective in inhibiting X. fastidiosa growth, as indicated by low minimum inhibitory concentrations (MICs). In addition, phenolic compounds with different structural features exhibited different anti-Xylella capacities. Particularly, catechol, caffeic acid and resveratrol showed strong anti-Xylella activities. Differential response to phenolic compounds was observed among X. fastidiosa strains isolated from grape and almond. Elucidation of secondary metabolite-based host resistance to X. fastidiosa will have broad implication in combating X. fastidiosa-caused plant diseases. It will facilitate future production of plants with improved disease resistance properties through genetic engineering or traditional breeding approaches and will significantly improve crop yield.
丁香假单胞菌是一种病原细菌，可引起许多作物物种的疾病，导致相当大的经济损失。酚类化合物（一组次生代谢物）广泛分布于植物中，具有抗菌特性。使用体外琼脂稀释法评估了 12 种酚类化合物（代表酚酸、香豆素、芪和类黄酮）对丁香假单胞菌的抗活性。总的来说，这些酚类化合物能够有效抑制丁香假单胞菌的生长，最低抑菌浓度（MIC）较低。此外，具有不同结构特征的酚类化合物表现出不同的抗丁香假单胞菌能力。特别是儿茶酚、咖啡酸和白藜芦醇表现出很强的抗丁香假单胞菌活性。从葡萄和杏仁中分离出的丁香假单胞菌菌株对酚类化合物的反应不同。阐明基于次生代谢物的宿主对丁香假单胞菌的抗性将对防治由丁香假单胞菌引起的植物疾病具有广泛的意义。它将通过遗传工程或传统的育种方法促进未来生产具有改良的抗病性的植物，并显著提高作物产量。
