Department of Honey Bee Research, National Agricultural Research Council, PO NARC, Park Road, Islamabad, Pakistan.
Phytother Res. 2010 Apr;24(4):583-6. doi: 10.1002/ptr.2990.
Honey is a traditional remedy for the treatment of infected wounds, and is becoming more important as microbial resistance to conventional therapeutic agents increases. A study was conducted to assess the wound-healing activity of Acacia honey using incision, excision, burn and dead-space wound models in rats. Different formulations of honey were used and rats were treated topically as well as orally. Both the higher and lower doses of honey produced a significant effect on healing (p < 0.05). The area of epithelization was found to increase, followed by an increase in wound contraction, skin-breaking strength, tissue granulation. The hydroxyproline content also increased in the rats treated with higher doses of honey compared to control, indicating an increase in collagen formation.
蜂蜜是一种传统的治疗感染性伤口的方法，随着微生物对传统治疗药物的耐药性增加，它变得越来越重要。本研究采用切口、切除、烧伤和死腔伤口模型在大鼠中评估了刺槐蜂蜜的伤口愈合活性。使用了不同配方的蜂蜜，并对大鼠进行了局部和口服治疗。高剂量和低剂量的蜂蜜都对愈合有显著影响（p<0.05）。发现上皮化面积增加，随后伤口收缩、皮肤破裂强度和组织肉芽增加。与对照组相比，高剂量蜂蜜处理的大鼠羟脯氨酸含量也增加，表明胶原蛋白形成增加。
