Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.
Int J Environ Res Public Health. 2018 Oct 25;15(11):2360. doi: 10.3390/ijerph15112360.
Wound healing is a complex process of recovering the forms and functions of injured tissues. The process is tightly regulated by multiple growth factors and cytokines released at the wound site. Any alterations that disrupt the healing processes would worsen the tissue damage and prolong repair process. Various conditions may contribute to impaired wound healing, including infections, underlying diseases and medications. Numerous studies on the potential of natural products with anti-inflammatory, antioxidant, antibacterial and pro-collagen synthesis properties as wound healing agents have been performed. Their medicinal properties can be contributed by the content of bioactive phytochemical constituents such as alkaloids, essential oils, flavonoids, tannins, saponins, and phenolic compounds in the natural products. This review highlights the in vitro, in vivo and clinical studies on wound healing promotions by the selected natural products and the mechanisms involved.
伤口愈合是一个复杂的过程,旨在恢复受伤组织的形态和功能。该过程受到多种生长因子和细胞因子的严格调控,这些因子在伤口部位释放。任何破坏愈合过程的改变都会加重组织损伤并延长修复过程。各种情况都可能导致伤口愈合受损,包括感染、潜在疾病和药物。人们已经对具有抗炎、抗氧化、抗菌和促进胶原蛋白合成特性的天然产物作为伤口愈合剂的潜力进行了大量研究。天然产物中的生物活性植物化学成分,如生物碱、精油、类黄酮、单宁、皂苷和酚类化合物,可能是其药用特性的来源。本综述重点介绍了选定天然产物在体外、体内和临床研究中促进伤口愈合的作用及其涉及的机制。