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药物研发困境与库拉四重奏合作。

Drug discovery dilemma and Cura quartet collaboration.

机构信息

Office of Planning and Enterprise Development, Georgetown University Medical Center, 4000 Reservoir Road, NW, Washington DC 20057, USA.

出版信息

Drug Discov Today. 2009 Nov;14(21-22):1006-10. doi: 10.1016/j.drudis.2009.09.007. Epub 2009 Oct 6.

Abstract

Many parties contribute to discovery of new drugs - academic researchers, industry scientists, government agencies, and disease foundation helping to corral the resources necessary to sustain research efforts - but it has never been more apparent until now that these parties must work together to accomplish the shared goal of improving health. At a recent conference at the Georgetown University Medical Center, a group of prominent scientists from the academic, industry, government and disease advocacy communities came together to discuss new paths forward for stronger inter-institutional collaboration to establish a framework for translating new discoveries into drugs, improving proof of concept (PoC) studies, and reducing attrition at the clinical stage of drug development.

摘要

许多方面都为新药的发现做出了贡献——学术研究人员、行业科学家、政府机构和疾病基金会,他们共同努力,汇集必要的资源来支持研究工作——但直到现在,这些方面必须携手合作,才能实现改善健康这一共同目标。在乔治敦大学医学中心最近举行的一次会议上,来自学术界、产业界、政府和疾病倡导界的一组杰出科学家齐聚一堂,讨论了加强机构间合作的新途径,以建立一个将新发现转化为药物的框架,改进概念验证(PoC)研究,并减少药物开发临床阶段的淘汰率。

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