Laboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgical and Materials Engineering & University Hospital Research Center, Laval University, Pav Adrien-Pouliot, 1745-E, Laval University, 1065 Ave de la Médecine, Québec City, QC, Canada.
Acta Biomater. 2010 May;6(5):1693-7. doi: 10.1016/j.actbio.2009.10.006. Epub 2009 Oct 6.
Interest in metallic degradable biomaterials research has been growing in the last decade. Both scientific journals and patent databases record a high increase in publications in this area. Biomedical implants with temporary function, such as coronary stents, are the targeted applications for this novel class of biomaterials. It is expected that stents made of degradable biomaterials, named biodegradable stents, will provide a temporary opening into a narrowed arterial vessel until the vessel remodels and will progressively disappear thereafter. Biodegradable stents made of metal have recently been progressed into preclinical tests in humans after their first introduction in early 2000s. By referring to patents and journal publications, this paper reviews the developments in biodegradable stents, with emphasis on those made of metals, starting from the first design ideas to validation testing.
过去十年，人们对可降解金属生物材料的研究兴趣日益浓厚。科学期刊和专利数据库都记录了该领域出版物的大量增加。具有临时功能的生物医学植入物，如冠状动脉支架，是这种新型生物材料的目标应用。预计由可降解生物材料制成的支架，即生物可降解支架，将在血管变窄时提供一个临时的开口，直到血管重塑，此后支架将逐渐消失。自 21 世纪初首次问世以来，最近可降解金属支架已进入人体临床前测试。本文通过参考专利和期刊出版物，综述了生物可降解支架的发展情况，重点介绍了那些由金属制成的支架，从最初的设计理念到验证测试。
