Laboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering, Pav Adrien-Pouliot, 1745-E Laval University, 1065 Ave de la Médecine, Québec City, QC, Canada.
Acta Biomater. 2010 May;6(5):1852-60. doi: 10.1016/j.actbio.2009.11.025. Epub 2009 Nov 23.
Biodegradable stents have shown their potential to be a valid alternative for the treatment of coronary artery occlusion. This new class of stents requires materials having excellent mechanical properties and controllable degradation behaviour without inducing toxicological problems. The properties of the currently considered gold standard material for stents, stainless steel 316L, were approached by new Fe-Mn alloys. The degradation characteristics of these Fe-Mn alloys were investigated including in vitro cell viability. A specific test bench was used to investigate the degradation in flow conditions simulating those of coronary artery. A water-soluble tetrazolium test method was used to study the effect of the alloy's degradation product to the viability of fibroblast cells. These tests have revealed the corrosion mechanism of the alloys. The degradation products consist of metal hydroxides and calcium/phosphorus layers. The alloys have shown low inhibition to fibroblast cells' metabolic activities. It is concluded that they demonstrate their potential to be developed as degradable metallic biomaterials.
可生物降解支架已显示出其作为治疗冠状动脉闭塞的有效替代方法的潜力。这种新型支架需要具有优异的机械性能和可控制降解行为的材料，而不会引起毒理学问题。目前被认为是支架的黄金标准材料的不锈钢 316L 通过新型 Fe-Mn 合金来实现。研究了这些 Fe-Mn 合金的降解特性，包括体外细胞活力。使用特定的试验台在模拟冠状动脉条件的流动条件下研究降解。使用水溶性四唑盐法研究合金降解产物对成纤维细胞活力的影响。这些测试揭示了合金的腐蚀机制。降解产物由金属氢氧化物和钙/磷层组成。合金对成纤维细胞代谢活性的抑制作用较低。因此，可以得出结论，它们具有作为可降解金属生物材料开发的潜力。
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