Abdel Hamid Mohamed A, Elborolosy Samir A, El Moshy Sara, Ammar Hany R, Sivasankaran S, Salem Walid S, Hassan Elham A
Department of Surgery, Anesthesiology and Radiology- Faculty of Veterinary Medicine- Cairo University, Giza, 12211, Egypt.
Oral and Maxillofacial Surgery Department- Faculty of Dentistry- Beni-Suef University, Beni-Suef, Egypt.
J Mater Sci Mater Med. 2025 Jun 25;36(1):56. doi: 10.1007/s10856-025-06890-7.
To investigate osteogenic potential of biodegradable nanostructured Cu/W/Co in Fe-Mn alloys for maxillofacial applications in an in vivo model. Nanostructured FeMn, FeMnCu, FeMnW FeMnCo alloys were fabricated. Ten mongrel dogs were included where five mandibular defects were induced in each dog. Defects were randomly allocated into 5 groups ((M) control defects covered by bone disc, (M0) implanted by FeMn alloy, (M1) implanted by FeMnCu alloy, (M2) implanted by FeMnW alloy, (M3) implanted by FeMnCo alloy). Dogs were euthanized at 12 weeks for cone beam computed tomography, histologic and immunohistologic evaluation, and gene expression of osteopontin and osteocalcin. Defects implanted with metal demonstrated thicker bone trabeculae mixed with lamellar bone while control defects (M) demonestrated immature woven bone. Quantitative evaluation of bone area %, area % of mature bone and expression of osteopentin and osteocalcin bone markers revealed a statistically significant highest bone area % and maturation in group M3 compared to M2, M1, M0, and M group. A statistically significant increase in bone area % and maturation was recorded in M2 group compared to M1, M0, and M groups. A significantly increased bone area % and maturation was recorded in M1 compared to control M group and also between M0 and M group. Incorporating Cu/W/Co into Fe-Mn alloys enhanced biocompatibility and improved bone regeneration suggesting its suitability for use in various orthopedic and dental applications. Biodegradable metal alloys could improve patient outcome, reduce the need for additional surgeries to remove nonbiodegradble implants. Biodegradable metal alloys could improve patient outcome, reduce the need for additional surgeries to remove nonbiodegradble implants.
在体内模型中研究可生物降解的纳米结构铜/钨/钴铁锰合金在颌面应用中的成骨潜力。制备了纳米结构的铁锰、铁锰铜、铁锰钨和铁锰钴合金。纳入10只杂种犬，每只犬诱导5处下颌骨缺损。缺损被随机分为5组（(M) 用骨盘覆盖的对照缺损，(M0) 植入铁锰合金，(M1) 植入铁锰铜合金，(M2) 植入铁锰钨合金，(M3) 植入铁锰钴合金）。12周时对犬实施安乐死，进行锥束计算机断层扫描、组织学和免疫组织学评估，以及骨桥蛋白和骨钙素的基因表达检测。植入金属的缺损显示出较厚的骨小梁并伴有板层骨，而对照缺损（M）显示为不成熟的编织骨。对骨面积百分比、成熟骨面积百分比以及骨桥蛋白和骨钙素骨标志物表达的定量评估显示，与M2、M1、M0和M组相比，M3组的骨面积百分比和成熟度在统计学上显著最高。与M1、M0和M组相比，M2组的骨面积百分比和成熟度在统计学上有显著增加。与对照M组相比以及M0和M组之间，M1组的骨面积百分比和成熟度显著增加。将铜/钨/钴掺入铁锰合金可增强生物相容性并改善骨再生，表明其适用于各种骨科和牙科应用。可生物降解的金属合金可改善患者预后，减少去除不可生物降解植入物的额外手术需求。可生物降解的金属合金可改善患者预后，减少去除不可生物降解植入物的额外手术需求。
