Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, 8093 Zurich, Switzerland.
Acta Biomater. 2010 May;6(5):1824-33. doi: 10.1016/j.actbio.2009.10.008. Epub 2009 Oct 6.
A design strategy deployed in developing new biodegradable Mg-Y-Zn alloys is summarized and the key factors influencing their suitability for medical applications are described. The Mg-Y-Zn alloys reveal microstructural features and mechanical characteristics expected to be appropriate for vascular intervention applications. The focus of this article lies in the evaluation of the degradation performance and biological response of the alloys with respect to their potential as implant materials (stents). The degradation characteristics analyzed by immersion testing and electrochemical impedance spectroscopy in simulated physiological media reveal slow and homogeneous degradation. In vitro cell tests using human umbilical vein endothelial cells indicate good cytocompatibility on the basis of the alloys' eluates (extracts). Animal studies carried out with pigs on Mg-2Y-1Zn (in wt.%) reveal an auspicious in vivo performance. Evaluation of preparations derived from implants in various types of tissues indicates homogeneous degradation and only limited gas formation during in vivo testing. The characteristics of the tissue reactions indicate good biocompatibility. The new Mg-Y-Zn alloys show an interesting combination of preferred microstructural, mechanical, electrochemical and biological properties, which make them very promising for degradable implant applications.
总结了开发新型可生物降解 Mg-Y-Zn 合金所采用的设计策略，并描述了影响其在医学应用中适用性的关键因素。Mg-Y-Zn 合金呈现出预期适用于血管介入应用的微观结构特征和力学特性。本文的重点在于评估合金作为植入材料（支架）的降解性能和生物反应。在模拟生理介质中通过浸泡试验和电化学阻抗谱分析得出的降解特性表明其具有缓慢且均匀的降解特性。使用人脐静脉内皮细胞进行的体外细胞试验表明，基于合金浸提液（提取物），其具有良好的细胞相容性。在猪身上进行的 Mg-2Y-1Zn（按重量计）合金的动物研究显示出良好的体内性能。对各种组织来源的植入物制备体的评估表明，在体内试验过程中存在均匀的降解和有限的气体形成。组织反应的特征表明其具有良好的生物相容性。新型 Mg-Y-Zn 合金表现出一系列令人感兴趣的微观结构、力学、电化学和生物学特性的组合，使其非常有前途可用于可降解植入物应用。
