Shahed Kazi Safowan, Fainor Matthew, Gullbrand Sarah E, Hast Michael W, Manogharan Guha
Department of Industrial and Manufacturing Engineering, Pennsylvania State University, State College, University Park, PA USA.
Department of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
In Vitro Model. 2024 Oct 8;3(4-6):157-168. doi: 10.1007/s44164-024-00077-0. eCollection 2024 Dec.
Zinc (Zn) and its alloys have been the focus of recent materials and manufacturing research for orthopaedic implants due to their favorable characteristics including desirable mechanical strength, biodegradability, and biocompatibility. In this research, a novel process involving additive manufacturing (AM) augmented casting was employed to fabricate zinc-magnesium (Zn-0.8 Mg) artifacts with surface lattices composed of triply periodic minimal surfaces (TPMS), specifically gyroid. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) analysis confirmed that Zn-Mg intermetallic phases formed at the grain boundary. Micro indentation testing resulted in hardness value ranging from 83.772 to 99.112 HV and an elastic modulus varying from 92.601 to 94.625 GPa. Results from in vitro cell culture experiments showed that cells robustly survived on both TPMS and solid scaffolds, confirming the suitability of the material and structure as biomedical implants. This work suggests that this novel hybrid manufacturing process may be a viable approach to fabricating next generation biodegradable orthopaedic implants.
锌（Zn）及其合金因其具有良好的机械强度、生物可降解性和生物相容性等特性，成为近年来骨科植入物材料与制造研究的焦点。在本研究中，采用了一种涉及增材制造（AM）增强铸造的新工艺来制造具有由三重周期极小曲面（TPMS）（具体为类螺旋面）构成的表面晶格的锌镁（Zn-0.8Mg）工件。扫描电子显微镜（SEM）和能量色散X射线光谱（EDS）分析证实，在晶界处形成了锌镁金属间相。微压痕测试得到的硬度值范围为83.772至99.112 HV，弹性模量在92.601至94.625 GPa之间变化。体外细胞培养实验结果表明，细胞在TPMS和实心支架上均能良好存活，证实了该材料和结构作为生物医学植入物的适用性。这项工作表明，这种新型混合制造工艺可能是制造下一代可生物降解骨科植入物的可行方法。
