Department of Neurology and Medicine, Aga Khan University, Karachi, Pakistan.
Neurol Sci. 2010 Apr;31(2):223-5. doi: 10.1007/s10072-009-0159-y. Epub 2009 Oct 9.
Our objective was to identify the outcome of patients treated with tissue plasminogen activator (r-tPa) in Pakistan and compare these data to available regional and international data. The charts of all patients treated with r-tPa for acute stroke at two centers in Pakistan (Aga Khan University, Karachi and Liaquat National hospital, Karachi) were retrospectively reviewed. We identified 21 patients. The utilization of tPa at Aga Khan Hospital was 18/1,185 patients (1.5%) from 2005 to 2007 while at Liaquat National Hospital was 3/575 patients (0.52%) over 1 year (2007). Mean time interval between stroke onset and start of r-tPa infusion was 169 min. Three patients (14%) developed fatal hemorrhage and two (10%) developed non-fatal hemorrhage. Four patients (19%) died. We identified protocol violations in seven patients (33%). In conclusion, the utilization of thrombolytic therapy is low and complication rate is high. Interventions for training physicians are needed.
我们的目的是确定在巴基斯坦接受组织型纤溶酶原激活剂（r-tPA）治疗的患者的结局，并将这些数据与现有的区域和国际数据进行比较。我们回顾了在巴基斯坦的两个中心（卡拉奇的阿迦汗大学和卡拉奇的利亚卡特国家医院）接受 r-tPA 治疗的所有急性脑卒中患者的病历。我们共确定了 21 名患者。阿迦汗医院 r-tPA 的使用率为 18/1185 名患者（1.5%），时间为 2005 年至 2007 年；而利亚卡特国家医院在 1 年期间（2007 年）的 r-tPA 使用率为 3/575 名患者（0.52%）。脑卒中发病到 r-tPA 输注开始的平均时间间隔为 169 分钟。3 名患者（14%）发生致命性出血，2 名患者（10%）发生非致命性出血。4 名患者（19%）死亡。我们在 7 名患者（33%）中发现了方案违反。总之，溶栓治疗的使用率较低，并发症发生率较高。需要对医生进行培训干预。
