Rehnqvist N
Department of Medicine, Danderyd Hospital, Sweden.
Cardiovasc Drugs Ther. 1990 Jun;4(3):675-9. doi: 10.1007/BF01856554.
Beta-adrenoreceptor blocking agents have been used to relieve symptoms mainly in patients with ischemic heart disease. Prophylactic use of beta blockade in patients after acute myocardial infarction has shown a reduction in total mortality and also in sudden death. The overall total mortality reduction amounts to about 30%, whereas the reduction in the sudden death rate is 50%. The mechanisms behind this reduction in sudden death are probably manifold. Antiarrhythmic effects in ischemic myocardium, prevention of new ischemia, and also perhaps other factors may play a role. Apart from the prevention effect in chronic ischemic heart disease, beta blockers have also been able to reduce the sudden death rate in the long QT syndrome and are suggested for use in congestive cardiomyopathy.
β-肾上腺素受体阻滞剂主要用于缓解缺血性心脏病患者的症状。急性心肌梗死后患者预防性使用β受体阻滞剂已显示总死亡率降低，猝死率也降低。总死亡率的总体降低约为30%，而猝死率的降低为50%。猝死率降低背后的机制可能是多方面的。缺血心肌的抗心律失常作用、预防新的缺血以及其他因素可能都发挥了作用。除了对慢性缺血性心脏病的预防作用外，β受体阻滞剂还能够降低长QT综合征的猝死率，并建议用于充血性心肌病。
