Central Clinical School, University of Queensland, Royal Brisbane and Women's Hospital, Brisbane, Queensland 4027, Australia.
Epilepsia. 2010 Jan;51(1):1-6. doi: 10.1111/j.1528-1167.2009.02328.x. Epub 2009 Oct 8.
Although it is known that Jacksonian epilepsy was first described by Bravais in 1827, some 40 years before Jackson began his work on the topic, little has been published on what Bravais wrote. Louis François Bravais (1801-1843) came from a French provincial family, which made a number of scientific, mainly botanical, contributions. In his Paris M.D. thesis, based on 25 instances of what he termed "hemiplegic epilepsy," Bravais described a set of unilateral epileptic seizure phenomena, including postseizure hemiparesis, very similar to those Jackson wrote about in 1870. However, Jackson accepted that the initially unilateral convulsive phenomena could spread to involve both sides of the body, whereas Bravais believed that this was incompatible with his entity, unless the generalization was a very rare event in the sufferer. Bravais in his account refused to go beyond descriptions of phenomena, whereas Jackson reasoned from the phenomena to a new concept of epileptogenesis, and also from them deduced that there must be localized representation of function in the cerebral cortex. Although Bravais had the priority, his work went largely unnoticed until Jackson's insights had made their impact on medical thinking.
尽管众所周知，杰克逊癫痫是由 Bravais 于 1827 年首次描述的，比杰克逊开始研究该主题早了 40 年，但关于 Bravais 的著作却鲜为人知。路易斯·弗朗索瓦·布拉瓦（Louis François Bravais，1801-1843 年）来自一个法国的外省家庭，他在科学领域做出了许多贡献，主要是在植物学方面。在他的巴黎医学博士论文中，基于他所谓的“偏瘫性癫痫”的 25 个病例，Bravais 描述了一系列单侧癫痫发作现象，包括发作后偏瘫，与杰克逊在 1870 年所描述的非常相似。然而，杰克逊认为最初的单侧惊厥现象可能会扩散到身体的两侧，而布拉瓦认为这与他的实体不符，除非这种泛化在患者中是非常罕见的事件。在他的描述中，Bravais 拒绝超越对现象的描述，而杰克逊则从现象中推导出一个新的癫痫发生概念，并且从这些现象中推断出大脑皮层中必须存在功能的局部表示。尽管 Bravais 有优先权，但他的工作在很大程度上被忽视了，直到杰克逊的见解对医学思维产生了影响。
