抗菌肽在心血管生理与疾病中的作用。

The role of antimicrobial peptides in cardiovascular physiology and disease.

作者信息

Li Yifeng

机构信息

Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

出版信息

Biochem Biophys Res Commun. 2009 Dec 18;390(3):363-7. doi: 10.1016/j.bbrc.2009.10.002. Epub 2009 Oct 7.

DOI:10.1016/j.bbrc.2009.10.002

PMID:19818331

Abstract

Antimicrobial peptides are natural peptide antibiotics, existing ubiquitously in both plant and animal kingdoms. They exhibit broad-spectrum antimicrobial activity and play an important role in host defense against invading microbes. Recently, these peptides have been shown to possess activities unrelated to direct microbial killing and be involved in the complex network of immune responses and inflammation. Thus, their role has now broadened beyond that of endogenous antibiotics. Because of their wide involvement in inflammatory response and the emerging role of inflammation in atherosclerosis, antimicrobial peptides have been proposed to represent an important link between inflammation and the pathogenesis of atherosclerotic cardiovascular diseases. This review highlights recent findings that support a role of these peptides in cardiovascular physiology and disease.

摘要

抗菌肽是天然的肽类抗生素，广泛存在于植物和动物界。它们具有广谱抗菌活性，在宿主抵御入侵微生物的防御中发挥重要作用。最近，这些肽已被证明具有与直接杀灭微生物无关的活性，并参与免疫反应和炎症的复杂网络。因此，它们的作用现已超出内源性抗生素的范畴。由于它们广泛参与炎症反应以及炎症在动脉粥样硬化中的新作用，抗菌肽被认为是炎症与动脉粥样硬化性心血管疾病发病机制之间的重要联系。本综述重点介绍了支持这些肽在心血管生理和疾病中发挥作用的最新研究发现。