Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Cell Signal. 2010 Feb;22(2):183-9. doi: 10.1016/j.cellsig.2009.10.001. Epub 2009 Oct 7.
The Rif and RhoD proteins belong to the Rho subfamily of small GTPases. Rif and RhoD have for too long remained in the shadows of the better known Rho GTPases Cdc42, Rac1 and RhoA. With this review article, our aim is to provide the currently available information regarding Rif and RhoD. Taken together, the data available to date indicate that Rif and RhoD have unique roles in the regulation of actin dynamics, and that RhoD can link actin reorganisation to endosomal vesicle transport.
Rif 和 RhoD 蛋白属于 Rho 亚家族的小 GTP 酶。 Rif 和 RhoD 长期以来一直处于更为知名的 Rho GTP 酶 Cdc42、Rac1 和 RhoA 的阴影之下。通过这篇综述文章，我们旨在提供目前关于 Rif 和 RhoD 的可用信息。综合来看，迄今为止可用的数据表明，Rif 和 RhoD 在调节肌动蛋白动力学方面具有独特的作用，并且 RhoD 可以将肌动蛋白重组与内体囊泡运输联系起来。
