Murphy C, Saffrich R, Grummt M, Gournier H, Rybin V, Rubino M, Auvinen P, Lütcke A, Parton R G, Zerial M
European Molecular Biology Laboratory, Heidelberg, Germany.
Nature. 1996 Dec 5;384(6608):427-32. doi: 10.1038/384427a0.
Vesicular transport is a dynamic process that requires coordinated interactions between membrane and cytoskeleton. The mechanisms and molecules integrating these interactions are unclear. A Rho protein, RhoD, might provide a molecular link between membrane traffic and the cytoskeleton. Activated RhoD causes rearrangements of the actin cytoskeleton and cell surface, and governs early endosome motility and distribution.
囊泡运输是一个动态过程，需要膜与细胞骨架之间进行协调相互作用。整合这些相互作用的机制和分子尚不清楚。一种Rho蛋白，即RhoD，可能在膜运输与细胞骨架之间提供分子联系。活化的RhoD会引起肌动蛋白细胞骨架和细胞表面的重排，并控制早期内体的运动性和分布。
