Department of Radiology, Nihon University School of Medicine, 30-1 Oyaguchi kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan.
Med Oncol. 2010 Sep;27(3):1027-30. doi: 10.1007/s12032-009-9328-3. Epub 2009 Oct 10.
Primary pleural synovial sarcoma is a rare disease with poor outcomes. Although hyperthermia therapy as part of a combined treatment regimen can offer improved local tumor control, only two reports of hyperthermia therapy for synovial sarcoma have appeared in the literature, and these sarcomas were not of pleuropulmonary origin. This report of an advanced inoperable primary pleural synovial sarcoma is the first to address the use of hyperthermia therapy in combination with chemoradiotherapy for this disease, together with radiological assessment following that therapy. Computed tomography performed after thermoradiation showed a decrease in tumor size and a characteristic unenhanced low-density area in the tumor suggesting that tumor necrosis resulted from the therapy. These image findings were helpful in assessing the tumor response to thermoradiation. We believe that hyperthermia therapy combined with chemoradiotherapy should be regarded as an option for advanced primary pleural synovial sarcoma. This would give computed tomography important role in evaluating this approach.
原发性胸膜滑膜肉瘤是一种罕见疾病，预后不良。虽然热疗作为综合治疗方案的一部分可以提供更好的局部肿瘤控制，但在文献中仅报道了两例滑膜肉瘤的热疗，而且这些肉瘤并非来自胸膜肺。本报告介绍了一例晚期不可手术的原发性胸膜滑膜肉瘤，这是首次针对该疾病联合应用热疗与放化疗，并在治疗后进行放射影像学评估。热放化疗后行 CT 检查显示肿瘤体积缩小，肿瘤内出现特征性无增强低密度区，提示肿瘤坏死是治疗的结果。这些影像学发现有助于评估肿瘤对热放化疗的反应。我们认为，热疗联合放化疗应被视为晚期原发性胸膜滑膜肉瘤的一种选择。这将使 CT 在评估该方法中发挥重要作用。
