Division of Infectious Diseases, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose, CA 95128, USA.
Crit Rev Microbiol. 2009;35(4):283-309. doi: 10.3109/10408410903213393.
The Candida parapsilosis family has emerged as a major opportunistic and nosocomial pathogen. It causes multifaceted pathology in immuno-compromised and normal hosts, notably low birth weight neonates. Its emergence may relate to an ability to colonize the skin, proliferate in glucose-containing solutions, and adhere to plastic. When clusters appear, determination of genetic relatedness among strains and identification of a common source are important. Its virulence appears associated with a capacity to produce biofilm and production of phospholipase and aspartyl protease. Further investigations of the host-pathogen interactions are needed. This review summarizes basic science, clinical and experimental information about C. parapsilosis.
近平滑假丝酵母家族已成为一种主要的机会性和医院获得性病原体。它在免疫功能低下和正常宿主中引起多方面的病理变化，尤其是低出生体重的新生儿。它的出现可能与定植皮肤、在含糖溶液中增殖和黏附塑料的能力有关。当出现菌群时，确定菌株间的遗传相关性和鉴定共同来源非常重要。其毒力似乎与产生生物膜和磷脂酶及天冬氨酸蛋白酶的能力有关。需要进一步研究宿主-病原体的相互作用。这篇综述总结了近平滑假丝酵母的基础科学、临床和实验信息。
