The Tudor Centre for Sexual Health, The Hillingdon Hospital, Uxbridge, Middlesex, UK.
J Dermatolog Treat. 2010 Sep;21(5):317-8. doi: 10.3109/09546630903271563.
Complex aphthosis, the occurrence of recurrent oral and genital aphthous ulceration without manifestations of systemic disease, is relatively uncommon and of unknown aetiology. We describe a case of complex aphthosis which began within weeks of stopping smoking. After failing to respond to conventional agents, the patient was successfully treated with nicotine lozenges. Recurrent aphthous stomatitis (RAS) is known to be less common in smokers and there have been previous reports of nicotine being used as successful treatments for RAS and Behçet's disease. We discuss the mechanisms of action of nicotine whereby nicotine could influence the natural history of aphthous ulceration. We recommend considering its use when conventional management has failed, particularly in ex-smokers.
复杂性阿弗他口炎，即反复发作的口腔和生殖器阿弗他溃疡而无系统性疾病表现，相对少见且病因不明。我们描述了一例复杂性阿弗他口炎，其在停止吸烟数周内发生。在常规药物治疗失败后，尼古丁口含片成功治疗了该患者。已知吸烟者复发性阿弗他口炎（RAS）较少见，且此前有报道称尼古丁可成功治疗 RAS 和白塞病。我们讨论了尼古丁的作用机制，尼古丁可能影响阿弗他溃疡的自然病程。我们建议在常规治疗失败时考虑使用尼古丁，特别是在曾经吸烟的患者中。
