Experimental Oncology 2, Centro di Riferimento Oncologico, IRCCS-National Cancer Institute, Aviano (PN), Italy.
Br J Haematol. 2010 Jan;148(1):115-8. doi: 10.1111/j.1365-2141.2009.07945.x. Epub 2009 Oct 11.
The effects of proliferative, apoptotic and anti-proliferative stimuli on interferon regulatory factor 4 (IRF4) expression by Reed-Sternberg (RS) cells were analysed using a panel of Hodgkin lymphoma (HL)-derived cell lines. IRF4 expressed by HL cells was consistently upregulated after CD40 engagement; IRF4 was downregulated by agonistic anti-CD95 antibodies in the FAS-sensitive HDLM-2 cells and after treatment with Adriamycin and Dacarbazine, two chemotherapic agents commonly used for HL treatment. These results demonstrated, for the first time, that IRF4 was up-modulated by CD40 engagement, and down-modulated by apoptotic and anti-proliferative signals, suggesting an involvement of IRF4 also in HL pathobiology.
通过一组霍奇金淋巴瘤 (HL) 衍生细胞系分析了促有丝分裂、凋亡和抗有丝分裂刺激对 Reed-Sternberg (RS) 细胞中干扰素调节因子 4 (IRF4) 表达的影响。HL 细胞表达的 IRF4 在 CD40 结合后持续上调；在 FAS 敏感的 HDLM-2 细胞中，激动性抗 CD95 抗体以及阿霉素和顺铂两种常用于 HL 治疗的化疗药物治疗后，IRF4 下调。这些结果首次表明，IRF4 被 CD40 结合上调，并被凋亡和抗有丝分裂信号下调，提示 IRF4 也参与 HL 病理生物学。
