Experimental Oncology, Centro di Riferimento Oncologico, IRCCS-National Cancer Institute, Aviano, PN, Italy.
Leuk Lymphoma. 2012 Feb;53(2):195-201. doi: 10.3109/10428194.2011.605190. Epub 2011 Aug 24.
Inflammation and cancer are two independent biological events that can play an interdependent role. The model of such interaction is represented by Hodgkin lymphoma (HL), where the microenvironment is dominated by an extensive mixed, potentially cellular inflammatory infiltrate that plays a decisive role in the pathobiology of HL. In this review we summarize updated information on the complex interactions between Hodgkin Reed-Sternberg (HRS) cells and their tissue microenvironment, highlighting the functional role of CD40/CD40L and interferon regulatory factor 4 (IRF4).
炎症和癌症是两种独立的生物学事件，它们可以相互作用。这种相互作用的模型以霍奇金淋巴瘤（HL）为代表，其中微环境主要由广泛的混合、潜在的细胞炎症浸润组成，在 HL 的病理生物学中起着决定性的作用。在这篇综述中，我们总结了霍奇金氏 Reed-Sternberg（HRS）细胞与其组织微环境之间复杂相互作用的最新信息，强调了 CD40/CD40L 和干扰素调节因子 4（IRF4）的功能作用。
