Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00165 - Rome, Italy.
Arch Dis Child. 2010 Jan;95(1):35-41. doi: 10.1136/adc.2008.153361. Epub 2009 Oct 11.
To investigate the prevalence of 14 viruses in infants with bronchiolitis and to study demographic and clinical differences in those with respiratory syncytial virus (RSV), human bocavirus (hBoV) and rhinovirus (RV) infection.
182 infants aged <12 months hospitalised for bronchiolitis were enrolled. Infants underwent nasal washing for the detection of RSV, influenza virus A and B, human coronavirus OC43, 229E, NL-63, HUK1, adenovirus, RV, parainfluenza 1-3, human metapneumovirus and hBoV. Demographic, clinical and laboratory data were obtained from parents and from patient medical files. Main outcome measurements were age, breastfeeding history, family smoking habits, family history for asthma and atopy, blood eosinophil count, chest radiological findings, clinical severity score and number of days of hospitalisation.
A virus was detected in 57.2% of the 182 infants. The most frequently detected viruses were RSV (41.2%), hBoV (12.2%) and RV (8.8%). Infants with dual infections (RSV and hBoV) had a higher clinical severity score and more days of hospitalisation than infants with RSV, RV and hBoV bronchiolitis (mean+/-SD: 4.7+2.4 vs 4.3+/-2.4 vs 3.0+/-2.0 vs 2.9+/-1.7, p<0.05; and 6.0+/-3.2 vs 5.3+/-2.4 vs 4.0+/-1.6 vs 3.9+/-1.1 days; p<0.05). Infants with RV infection had higher blood eosinophil counts than infants with bronchiolitis from RSV and hBoV (307+/-436 vs 138+/-168 vs 89+/-19 n/mm(3); p<0.05).
Although the major pathogen responsible for bronchiolitis remains RSV, the infection can also be caused by RV and hBoV. Demographic characteristics and clinical severity of the disease may depend on the number of viruses or on the specific virus detected.
调查毛细支气管炎患儿中 14 种病毒的流行情况，并研究呼吸道合胞病毒（RSV）、人博卡病毒（hBoV）和鼻病毒（RV）感染患儿的人口统计学和临床差异。
纳入 182 例因毛细支气管炎住院的＜12 个月龄婴儿。对婴儿进行鼻冲洗，以检测 RSV、流感病毒 A 和 B、人冠状病毒 OC43、229E、NL-63、HUK1、腺病毒、RV、副流感病毒 1-3、人偏肺病毒和 hBoV。从父母和患者病历中获取人口统计学、临床和实验室数据。主要观察指标为年龄、母乳喂养史、家庭吸烟习惯、哮喘和特应性家族史、血嗜酸性粒细胞计数、胸部影像学表现、临床严重程度评分和住院天数。
182 例婴儿中，57.2%的患儿检测到病毒。最常检测到的病毒是 RSV（41.2%）、hBoV（12.2%）和 RV（8.8%）。与 RSV、RV 和 hBoV 毛细支气管炎患儿相比，双重感染（RSV 和 hBoV）患儿的临床严重程度评分和住院天数更高（均数±标准差：4.7±2.4 比 4.3±2.4 比 3.0±2.0 比 2.9±1.7，p＜0.05；6.0±3.2 比 5.3±2.4 比 4.0±1.6 比 3.9±1.1 天；p＜0.05）。与 RSV 和 hBoV 毛细支气管炎患儿相比，RV 感染患儿的血嗜酸性粒细胞计数更高（307±436 比 138±168 比 89±19 n/mm3；p＜0.05）。
虽然 RSV 仍是导致毛细支气管炎的主要病原体，但 RV 和 hBoV 也可引起该感染。疾病的人口统计学特征和严重程度可能取决于病毒的数量或具体检测到的病毒。
