I期子宫内膜癌患者的血清脯氨酰肽酶活性和氧化状态

Serum prolidase activity and oxidative status in patients with stage I endometrial cancer.

作者信息

Arioz Dagistan Tolga, Camuzcuoglu Hakan, Toy Harun, Kurt Sefa, Celik Hakim, Aksoy Nurten

机构信息

Department of Obstetrics and Gynecology, Medical School, Afyonkarahisar Kocatepe University, Afyonkarahisar, Turkey.

出版信息

Int J Gynecol Cancer. 2009 Oct;19(7):1244-7. doi: 10.1111/IGC.0b013e3181af711e.

DOI:10.1111/IGC.0b013e3181af711e

PMID:19823062

Abstract

INTRODUCTION

We aimed to investigate the serum prolidase activity, total oxidant status (TOS), total antioxidant capacity (TAC), and total free sulfhydryl (-SH) groups in patients with stage I endometrial cancer.

METHODS

Serum prolidase activity, TOS, TAC, and -SH levels were measured in patients with endometrial cancer (n = 23) and controls (n = 25).

RESULTS

Serum prolidase activity and TOS were significantly higher in patients with endometrial cancer than in controls (P = 0.02 and P = 0.02, respectively), whereas TAC and -SH group levels were significantly lower (P = 0.004 and P = 0.001, respectively). There were no differences between surgical stages IA and IB or between stages IB and IC (P = 0.189 and P = 0.161, respectively) with respect to prolidase levels, whereas there was a significant difference between stages IA and IC (P < 0.001).

CONCLUSIONS

Increased serum prolidase activity and oxidative stress may be associated with endometrial cancer, and increased serum prolidase activity may be related to local invasion of endometrial cancer.

摘要

引言

我们旨在研究I期子宫内膜癌患者的血清脯氨酰二肽氨基肽酶活性、总氧化状态（TOS）、总抗氧化能力（TAC）和总游离巯基（-SH）基团。

方法

测定子宫内膜癌患者（n = 23）和对照组（n = 25）的血清脯氨酰二肽氨基肽酶活性、TOS、TAC和-SH水平。

结果

子宫内膜癌患者的血清脯氨酰二肽氨基肽酶活性和TOS显著高于对照组（分别为P = 0.02和P = 0.02），而TAC和-SH基团水平显著降低（分别为P = 0.004和P = 0.001）。就脯氨酰二肽氨基肽酶水平而言，IA期和IB期之间或IB期和IC期之间无差异（分别为P = 0.189和P = 0.161），而IA期和IC期之间存在显著差异（P < 0.001）。