Gómez Evangelina, Zoth Silvina Chimeno, Berinstein Analía
Instituto de Biotecnología, CICVyA, INTA, Castelar, Buenos Aires, Argentina.
Hum Vaccin. 2009 Nov;5(11):738-44. doi: 10.4161/hv.5.11.9879. Epub 2009 Nov 23.
The worldwide need to produce safe and affordable vaccines with a minimum requirement of manufacture and processing, together with the advancements achieved in biotechnology, have promoted the development of efficient alternatives to traditional ones. One of the available options is the use of transgenic plants, not only as a protein production system but as an antigen transportation system as well, being capable of delivering antigens to the mucosal immune targets, becoming what is known as edible vaccines. The versatility of the plant production system allows for instance, to express and to accumulate foreign antigens in edible plant tissues. Thus, the hypothesis for the choice of plant-based vaccines is that once a plant-based vaccine is eaten, the susceptible host mounts a mucosal immune response against the antigen that is expressed in the plant, becoming protected against the pathogen from which the antigen was selected. This idea is still under study. Here, we described the basis of the system, the promising future and the possible drawbacks.
全球对生产具有最低制造和加工要求的安全且价格合理的疫苗的需求，以及生物技术取得的进展，推动了传统疫苗高效替代品的开发。现有的选择之一是使用转基因植物，它不仅作为蛋白质生产系统，还作为抗原运输系统，能够将抗原递送至黏膜免疫靶点，成为所谓的可食用疫苗。植物生产系统的多功能性使得例如能够在可食用植物组织中表达和积累外源抗原。因此，选择基于植物的疫苗的假设是，一旦食用基于植物的疫苗，易感宿主就会针对植物中表达的抗原产生黏膜免疫反应，从而免受选择该抗原的病原体的侵害。这一想法仍在研究中。在此，我们描述了该系统的基础、光明的未来以及可能存在的缺点。
