Long Beach Memorial Heart & Vascular Institute, Long Beach Memorial Medical Center, Long Beach, CA, USA.
Cardiol Rev. 2009 Nov-Dec;17(6):280-2. doi: 10.1097/CRD.0b013e3181bad02d.
Hyperbaric oxygen (HBO) was first used by placing a patient with the "bends" in a pressure chamber and increasing the pressure to 3 atm with 100% oxygen. It was soon recognized that HBO could also facilitate wound healing in infected ischemic extremities. Before the pump oxygenator was developed, it was also shown to facilitate corrective surgery, especially in congenital heart disease. In 1997, after encouraging animal work, HBO therapy was used in conjunction with thrombolytics to reduce the magnitude of injury in patients with acute myocardial infarction. The benefit is probably due to the decrease in reperfusion injury, which has been shown to be a major cause of myocardial cell death when the culprit artery is opened with a catheter. The most recent development is to infuse saline saturated with HBO into the opened coronary artery immediately after angioplasty. An advantage of this treatment has been demonstrated in experimental animals and in man. Future applications of HBO treatment in cardiovascular disease await more research, but at this time it seems to have considerable promise.
高压氧（HBO）最初是通过将患有“减压病”的患者置于压力舱中并用 100%氧气将压力增加到 3 个大气压来使用的。很快就发现，HBO 还可以促进感染性缺血肢体的伤口愈合。在开发出泵式氧气浓缩器之前，它还被证明可以促进矫形手术，特别是在先天性心脏病中。1997 年，在令人鼓舞的动物研究工作之后，HBO 治疗与溶栓剂联合使用，以减少急性心肌梗死患者的损伤程度。其益处可能归因于再灌注损伤的减少，当通过导管打开罪犯动脉时，再灌注损伤已被证明是心肌细胞死亡的主要原因。最近的进展是在经皮冠状动脉成形术后立即将饱和 HBO 的生理盐水注入开放的冠状动脉。这种治疗方法的优势已在实验动物和人类中得到证实。高压氧治疗在心血管疾病中的未来应用有待更多的研究，但目前看来，它似乎有很大的前景。
