Caramia G
Unit of Pediatrics and Neonatology, G. Salesi Specialized Hospital for Mothers and Children, Ancona, Italy.
Minerva Gastroenterol Dietol. 2009 Sep;55(3):237-72.
Starting from Metchnikoff's theory of cell-mediated immunity and work on lactobacillus over 100 years ago, more and more applications for probiotics have been developed. Research into the health properties of probiotics has focused primarily on two areas: the interaction between intestinal microflora and enterocytes and the immune system and the use of probiotic products in the treatment of gastrointestinal diseases in adults and children. This review examines recent studies on the clinical use of monostrain and multistrain probiotic products in gastroenterology. The most widely studied strains are lactobacilli and yeasts, specifically, Lacto-bacillus rhamnosus GG and Saccharomices boulardii; the gastrointestinal disorders most commonly treated with probiotics are inflammatory bowel disease and dysbiosis, both of which clinically manifest as diarrhea.
从100多年前梅契尼科夫的细胞介导免疫理论以及对乳酸菌的研究开始，益生菌的应用越来越多。对益生菌健康特性的研究主要集中在两个领域：肠道微生物群与肠上皮细胞和免疫系统之间的相互作用，以及益生菌产品在成人和儿童胃肠道疾病治疗中的应用。这篇综述考察了单菌株和多菌株益生菌产品在胃肠病学临床应用方面的最新研究。研究最为广泛的菌株是乳酸菌和酵母菌，具体而言，鼠李糖乳杆菌GG和布拉酵母菌；益生菌最常用于治疗的胃肠道疾病是炎症性肠病和菌群失调，这两种疾病在临床上均表现为腹泻。
