[黄芩中的黄酮类化合物及其生物活性]
[Flavonoids from Scutellaria baicalensis and their bioactivities].
作者信息
Zhou Xi Qin, Liang Hong, Lu Xin Hua, Cai Shao Qing, Wang Bin, Zhao Yu Ying
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.
出版信息
Beijing Da Xue Xue Bao Yi Xue Ban. 2009 Oct 18;41(5):578-84.
OBJECTIVE
To study the flavonoids of Scutellaria baicalensis and their bioactivities.
METHODS
Chromatographic methods were used to separate compounds, spectral methods were used to determine the structures and bioactivities of the flavonoids were screened in several models in vitro.
RESULTS
Nine compounds were isolated and identified as baicalein (1), wogonin (2), oroxylin A (3), 5, 7, 2', 6'-tetrahydroxyflavone (4), viscidulin III (5), baicalin (6), wogonoside (7), oroxylin A-7-O-beta-D-glucuronide (8) and chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside (9).
CONCLUSION
Baicalein had good anti-bacteria activity, and some compounds showed inhibiting activity against IL-1beta converting enzyme. The 13C NMR data of compounds 9 were assigned correctly by 2D nuclear magnetic resonance (NMR).
目的
研究黄芩中的黄酮类化合物及其生物活性。
方法
采用色谱法分离化合物，光谱法确定结构，并在多种体外模型中筛选黄酮类化合物的生物活性。
结果
分离并鉴定出9种化合物，分别为黄芩素（1）、汉黄芩素（2）、木犀草素（3）、5,7,2',6'-四羟基黄酮（4）、粘毛黄芩素III（5）、黄芩苷（6）、汉黄芩苷（7）、木犀草素-7-O-β-D-葡萄糖醛酸苷（8）和白杨素-6-C-α-L-阿拉伯吡喃糖基-8-C-β-D-葡萄糖吡喃糖苷（9）。
结论
黄芩素具有良好的抗菌活性，部分化合物对白细胞介素-1β转化酶具有抑制活性。通过二维核磁共振（NMR）正确归属了化合物9的13C NMR数据。
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