Bruno Antonio, Riganello Deborah, Marino Antonio
Institute of Psychiatric Rehabilitation "Villa S. Agata", Via Rimembranze 36, 89131 Gallina, Reggio Calabria Italy.
Cases J. 2009 Jul 23;2:7288. doi: 10.4076/1757-1626-2-7288.
Borderline personality disorder is a chronic mental disorder associated with severe psychosocial impairment and morbidity, greater usage of mental health resources, and a high mortality rate. Although there is no drug with an approved indication for this disorder, pharmacological treatment is a common practice based on the specific benefit of the drugs on the remission of the core symptoms of the disease.
Authors reported the case of a 37-year-old obese woman with borderline personality disorder, obsessive-compulsive symptoms and bulimia nervosa treated with aripiprazole and topiramate. Co-administration of aripiprazole and topiramate produced a significant improvement of all psychopathological dimensions, obsessive-compulsive symptoms, and eating disorder.
Co-administration of aripiprazole and topiramate could be a safe and effective long-term treatment for improving not only the symptoms of borderline personality disorder but also the associated health-related quality of life and interpersonal problems.
边缘型人格障碍是一种慢性精神障碍，与严重的心理社会功能损害和发病率、更多地使用心理健康资源以及高死亡率相关。尽管目前尚无获批用于该障碍的药物，但基于药物对疾病核心症状缓解的特定益处，药物治疗仍是一种常见的做法。
作者报告了一例37岁患有边缘型人格障碍、强迫症状和神经性贪食症的肥胖女性，使用阿立哌唑和托吡酯进行治疗。阿立哌唑和托吡酯联合使用使所有精神病理学维度、强迫症状和饮食障碍均有显著改善。
阿立哌唑和托吡酯联合使用可能是一种安全有效的长期治疗方法，不仅可以改善边缘型人格障碍的症状，还可以改善与之相关的健康相关生活质量和人际关系问题。
