Oh Joo Youn, Kim Mee Kum, Park Joong Shin, Wee Won Ryang
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Cases J. 2009 May 26;2:7444. doi: 10.1186/1757-1626-2-7444.
Biomechanical changes in the cornea during pregnancy might lead to pathological conditions such as corneal perforation or melting.
A 33-year-old Asian female who underwent penetrating keratoplasty in both eyes developed corneal melting in the right eye and marginal keratitis in the left eye in her fifth month of pregnancy. Marginal keratitis in the left eye immediately subsided with topical steroid therapy. However, spontaneous corneal melting progressed in the right eye, despite oral steroid therapy and amniotic membrane transplantation. We performed tectonic penetrating keratoplasty and corneoscleral grafting in the right eye.
We advise caution in the ophthalmologic care of pregnant patients who have preexisting corneal thinning disorders or who have undergone multiple corneal surgeries, because physiologic changes during pregnancy might contribute to corneal changes leading to spontaneous melting especially in patients with compromised cornea.
孕期角膜的生物力学变化可能导致诸如角膜穿孔或角膜溶解等病理状况。
一名33岁的亚洲女性，双眼接受了穿透性角膜移植术，在孕期第五个月时右眼发生角膜溶解，左眼出现边缘性角膜炎。左眼的边缘性角膜炎经局部类固醇治疗后立即消退。然而，尽管进行了口服类固醇治疗和羊膜移植，右眼的角膜自发溶解仍在进展。我们对右眼进行了结构性穿透性角膜移植术和角巩膜移植术。
对于患有既往角膜变薄疾病或接受过多次角膜手术的孕妇，我们建议在眼科护理中要谨慎，因为孕期的生理变化可能导致角膜变化，进而引发自发溶解，尤其是在角膜受损的患者中。
