Rainville Christa, Khan Yasir, Tisman Glenn
A Medical Corporation 13025 Bailey Street, Suite A, Whittier, CA 90601 USA.
Cases J. 2009 Jul 21;2:8390. doi: 10.4076/1757-1626-2-8390.
Serum vitamin D levels measured as 25-hydroxyvitamin D have been shown to be low in cancer patients, including breast cancer patients. However, the vitamin D status has yet to be studied in different breast cancer phenotypes: luminal A, luminal B, HER2+/ER-, and triple negative comprising the majority of basal-like.
Fifteen triple-negative breast cancer patients have presented to our medical oncology office in the last five years. Thirteen of these fifteen patients (87%) were found to be vitamin D deficient, defined as serum 25(OH)D less than 80 nmol/L, prior to initiation of adjuvant therapy. Ninety-one breast cancer patients from our office were classified as: luminal A (ER+ &/or PR+ and HER2-), luminal B (ER+ &/or PR+ and HER2+), HER2+/ER- (ER-, PR-, and HER2+), and triple-negative or basal-like (ER-, PR-, and HER2-). A normal mean was found from 78 volunteers. The breast cancer patients were found to be statistically different than the normal population. The triple-negative phenotype was found to be the most statistically different than the normal population.
The triple-negative breast cancer phenotype has the lowest average vitamin D level and the highest percentage of patients that are vitamin D deficient. These data suggests that low vitamin D levels are characteristic of the triple-negative phenotype.
以25-羟基维生素D测量的血清维生素D水平在癌症患者中，包括乳腺癌患者中已显示较低。然而，维生素D状态尚未在不同的乳腺癌表型中进行研究：管腔A型、管腔B型、HER2阳性/雌激素受体阴性型以及构成大多数基底样型的三阴性型。
在过去五年中，有15例三阴性乳腺癌患者前来我们的肿瘤内科门诊。在开始辅助治疗之前，这15例患者中有13例（87%）被发现维生素D缺乏，定义为血清25(OH)D低于80 nmol/L。我们门诊的91例乳腺癌患者被分类为：管腔A型（雌激素受体阳性和/或孕激素受体阳性且HER2阴性）、管腔B型（雌激素受体阳性和/或孕激素受体阳性且HER2阳性）、HER2阳性/雌激素受体阴性型（雌激素受体阴性、孕激素受体阴性且HER2阳性）以及三阴性或基底样型（雌激素受体阴性、孕激素受体阴性且HER2阴性）。从78名志愿者中得出正常均值。发现乳腺癌患者与正常人群在统计学上有差异。发现三阴性表型与正常人群在统计学上差异最大。
三阴性乳腺癌表型的平均维生素D水平最低，维生素D缺乏患者的比例最高。这些数据表明低维生素D水平是三阴性表型的特征。
