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[高压氧在直线加速器放射外科治疗后放射性坏死和症状性脑水肿治疗中的应用价值]

[Usefulness of hyperbaric oxygen in the treatment of radionecrosis and symptomatic brain edema after LINAC radiosurgery].

作者信息

Pérez-Espejo M A, García-Fernández R, Tobarra-González B M, Palma-Copete J D, González-López A, De la Fuente-Muñoz I, Salinas-Ramos J, Felipe-Murcia M, Martínez-Lage J F, Fernández-Pérez J, Romero J M

机构信息

Servicios de Neurocirugía. Hospital Universitario "Virgen Arrixaca". Murcia. España.

出版信息

Neurocirugia (Astur). 2009 Oct;20(5):449-53.

Abstract

Radionecrosis with brain edema is a complication of radiosurgery. Three female patients harbouring a frontal pole, petrous and parasagital parietoocipital meningiomas respectively who had been treated with LINAC radiosurgery are presented. Those patients developed, between two and eight months later, a severe symptomatic radionecrosis with a huge brain edema resistant to the usual steroid therapy. Only after 40 sessions of hyperbaric oxygen, a good remission of the lesions was obtained. There are few cases reported in the literature with such a good outcome. Consequentely, this therapy must be taken into account to treat this type of radiosurgical complication before considering surgery.

摘要

放射性坏死伴脑水肿是放射外科手术的一种并发症。本文介绍了三名分别患有额极、岩部和矢状窦旁顶枕部脑膜瘤的女性患者,她们均接受了直线加速器放射外科治疗。这些患者在治疗后两到八个月内出现了严重的症状性放射性坏死,并伴有巨大的脑水肿,常规类固醇治疗无效。仅在接受40次高压氧治疗后,病变才得到良好缓解。文献中报道的此类良好结果的病例很少。因此,在考虑手术之前,必须考虑采用这种疗法来治疗这类放射外科并发症。

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