具有良好抗菌活性的4-氨基苯乙酸衍生物的制备
Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.
作者信息
Bedair Ahmed H, Ali Fawzy M, El-Agrody Ahmed M, Eid Fathy A, El-Nassag Mohammed A A, El-Sherbeny Gamal
机构信息
Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
出版信息
Acta Pharm. 2006 Sep;56(3):273-84.
Condensation of 4-aminophenylacetic acid with phthalic anhydride gave (dioxoisoindolin-2-yl)phenylacetic acid (1), which was employed as the key intermediate in the synthesis of title compounds 2-8. The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Antimicrobial activities were studied and some of the compounds showed promising results.
4-氨基苯乙酸与邻苯二甲酸酐缩合得到（二氧代异吲哚啉-2-基）苯乙酸（1），其被用作合成标题化合物2-8的关键中间体。通过分析和光谱数据（红外光谱、1H核磁共振谱、13C核磁共振谱和质谱）对产物进行了表征。研究了抗菌活性，一些化合物显示出有前景的结果。
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