Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu City, Oita, Japan.
Clin Microbiol Infect. 2010 Aug;16(8):1264-9. doi: 10.1111/j.1469-0691.2009.03081.x. Epub 2009 Oct 14.
The dupA gene of Helicobacter pylori was suggested to be a risk factor for duodenal ulcer but protective against gastric cancer. The present study aimed to re-examine the role of dupA in H. pylori-infected Japanese patients. We found that dupA status was not associated with any gastroduodenal disease, histological score of chronic gastritis or with the extent of interleukin-8 production from gastric cell lines. These results indicate that dupA is unlikely to be a virulence factor of H. pylori in the Japanese population.
幽门螺杆菌的 dupA 基因被认为是十二指肠溃疡的危险因素，但对胃癌有保护作用。本研究旨在重新检验 dupA 在日本幽门螺杆菌感染患者中的作用。我们发现，dupA 状态与任何胃十二指肠疾病、慢性胃炎的组织学评分或胃细胞系产生的白细胞介素-8 的程度均无关。这些结果表明，dupA 不太可能是日本人群中幽门螺杆菌的毒力因子。
