Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju 52727, Republic of Korea.
BK21 Center for Human Resource Development in the Bio-Health Industry, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea.
J Microbiol Biotechnol. 2021 Mar 28;31(3):368-379. doi: 10.4014/jmb.2101.01023.
Two virulence factors of , and , have been known to play a role in the development of severe gastric symptoms. However, they are not always associated with peptic ulcer or gastric cancer. To predict the disease outcome more accurately, it is necessary to understand the risk of severe symptoms linked to other virulence factors. Several other virulence factors of have also been reported to be associated with disease outcomes, although there are many controversial descriptions. isolates from Koreans may be useful in evaluating the relevance of other virulence factors to clinical symptoms of gastric diseases because the majority of Koreans are infected by toxigenic strains of bearing and . In this study, a total of 116 strains from Korean patients with chronic gastritis, peptic ulcers, and gastric cancers were genotyped. The presence of virulence factors , , , , and the extremely strong vacuolating toxin was found to contribute significantly to the development of severe gastric symptoms. The genotype combination // was the most predictable determinant for the development of severe symptoms, and the presence of was found to be the most critical factor. This study provides important information on the virulence factors that contribute to the development of severe gastric symptoms and will assist in predicting clinical disease outcomes due to infection.
已知 两种毒力因子 和 在严重胃部症状的发展中起作用。然而，它们并不总是与消化性溃疡或胃癌相关。为了更准确地预测疾病结果，有必要了解与其他毒力因子相关的严重症状的风险。已经报道了其他几种 的毒力因子与疾病结果相关，尽管有许多有争议的描述。来自韩国的 分离株可能有助于评估其他毒力因子与胃部疾病临床症状的相关性，因为大多数韩国人感染的是携带 和 的产毒菌株。在这项研究中，对来自韩国慢性胃炎、消化性溃疡和胃癌患者的 116 株进行了基因分型。发现毒力因子 、 、 、 和极强的空泡毒素的存在与严重胃部症状的发展有显著相关性。// 的基因型组合是预测严重症状发展的最具预测性的决定因素，而 的存在是最关键的因素。这项研究提供了与严重胃部症状发展相关的毒力因子的重要信息，并将有助于预测 感染引起的临床疾病结果。
